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Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissues

18 Jul 2022

Abstract excerpt

Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs are derived from different organs with similar morphologies, and it is challenging to distinguish the origin of metastatic SCCs. Here we report a deep proteomic analysis of 333 SCCs of 17 organs and 69 ACs of 7 organs. Proteomic comparison between SCCs and ACs identifies distinguishable pivotal...

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PMID: 35851595
DOI: 10.1038/s41467-022-31719-0

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