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Stromal architecture and fibroblast subpopulations with opposing effects on outcomes in hepatocellular carcinoma

28 Jan 2025

Abstract excerpt

Dissecting the spatial heterogeneity of cancer-associated fibroblasts (CAFs) is vital for understanding tumor biology and therapeutic design. By combining pathological image analysis with spatial proteomics, we revealed two stromal archetypes in hepatocellular carcinoma (HCC) with different biological functions and extracellular matrix compositions. Using paired single-cell RNA and epigenomic sequencing with...

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PMID: 39870619
DOI: 10.1038/s41421-024-00747-z

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