Article
The structure of genealogies in the presence of purifying selection: a fitness-class coalescent.
Genetics - 1 Feb 2012
Walczak Aleksandra M, Nicolaisen Lauren E, Plotkin Joshua B, Desai Michael M
Abstract excerpt
Compared to a neutral model, purifying selection distorts the structure of genealogies and hence alters the patterns of sampled genetic variation. Although these distortions may be common in nature, our understanding of how we expect purifying selection to affect patterns of molecular variation remains incomplete. Genealogical approaches such as coalescent theory have proven difficult to generalize to situations...
Topics
- Algorithms
- Computer Simulation
- Evolution, Molecular
- Genealogy and Heraldry
- Genetic Fitness
- Genetic Linkage
- Genetic Variation
- Heterozygote
- Models, Genetic
- Mutation
- Population Density
- Probability
- Selection, Genetic