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Article

Specific types of male infertility are correlated with T cell exhaustion or senescence signatures

24 Jan 2025

Abstract excerpt

The association between male infertility and health status has yet to be unraveled. Here, by combining multiparameter phenotyping and scRNA-seq, we delineate the immune status of infertile men both at the semen and systemic levels. We first observe that young infertile men have a pro-inflammatory milieu with increased frequency of myeloid cells and inflammatory mediators in the seminal fluid and the peripheral...

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PMID: 39856063
DOI: 10.1038/s41467-025-56193-2

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