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Article

Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes.

Genes & genomics - 1 Oct 2020

Kim Sung-Soo, Lee Sang In, Jin Hyun-Seok, Park Sangjung

Abstract excerpt

BACKGROUND: Vitamin D (Vit. D) is used extensively during tuberculosis treatment. Low levels of serum Vit. D increase the risk of active tuberculosis development. Altered expression of the proteins involved in Vit. D metabolism impairs cathelicidin production, thereby increasing the host susceptibility to tuberculosis. OBJECTIVE: We are trying to investigate whether single nucleotide polymorphisms (SNPs) in LRP2,...

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PMID: 32803705
DOI: 10.1007/s13258-020-00971-3

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