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Article

Dedicator of cytokinesis 2 regulates cytoskeletal actin dynamics and is essential for platelet biogenesis and functions.

Cardiovascular research - 29 Apr 2025

Ji Jiani, Xu Xulin, Zhang Lili, Liu Shuang, Chen Jiayi, Gao Huihui, Xiang Limin, Li Yaofeng, Xu Hui, Chen Yaobing, Xiang Huiqin, Chen Shuai, Han Yunyun, Tang Zhaoming, Wang Xuanbin, Shi Xiaofeng, Mao Jianhua, Xi Xiaodong, Wang Jinyu, Fang Chao

Abstract excerpt

AIMS: Dedicator of cytokinesis 2 (DOCK2), a member of the DOCK family of guanine nucleotide exchange factors that specifically act on the Rho GTPases including Rac and Cdc42, plays pivotal roles in the regulation of leukocyte homeostasis. However, its functions in platelets remain unknown. METHODS AND RESULTS: Using mice with genetic deficiency of DOCK2 (Dock2-/-), we showed that Dock2-/- mice exhibited a...

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Identifiers

PMID: 39836640
DOI: 10.1093/cvr/cvaf009

Genes

DOCK2

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