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Article

Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2016

Sung Derek C, Bowen Caitlin J, Vaidya Kiran A, Zhou Jingjing, Chapurin Nikita, Recknagel Andrew, Zhou Bin, Chen Jonathan, Kotlikoff Michael, Butcher Jonathan T

Abstract excerpt

OBJECTIVE: Calcific aortic valve (AoV) disease is a significant clinical problem for which the regulatory mechanisms are poorly understood. Enhanced cell-cell adhesion is a common mechanism of cellular aggregation, but its role in calcific lesion formation is not known. Cadherin-11 (Cad-11) has been associated with lesion formation in vitro, but its function during adult valve homeostasis and pathogenesis is not...

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Identifiers

PMID: 27312222
DOI: 10.1161/ATVBAHA.116.307812
PMCID: PMC4965289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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