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Gene set correlation enrichment analysis for interpreting and annotating gene expression profiles.

Nucleic acids research - 9 Feb 2024

Chang Lan-Yun, Lee Meng-Zhan, Wu Yujia, Lee Wen-Kai, Ma Chia-Liang, Chang Jun-Mao, Chen Ciao-Wen, Huang Tzu-Chun, Lee Chia-Hwa, Lee Jih-Chin, Tseng Yu-Yao, Lin Chun-Yu

Abstract excerpt

Pathway analysis, including nontopology-based (non-TB) and topology-based (TB) methods, is widely used to interpret the biological phenomena underlying differences in expression data between two phenotypes. By considering dependencies and interactions between genes, TB methods usually perform better than non-TB methods in identifying pathways that include closely relevant or directly causative genes for a given...

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PMID: 38096046
DOI: 10.1093/nar/gkad1187
PMCID: PMC10853793

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