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Article

Engineered initiator tRNAs can effectively start translation at non-AUG start codons and diversify N-terminal amino acids for mRNA Display.

Nucleic acids research - 11 Jan 2025

Helmling Christina, Chan Alix I, Cunningham Christian N

Abstract excerpt

mRNA display is an effective tool to identify high-affinity macrocyclic binders for challenging protein targets. The success of an mRNA display selection is dependent on generating highly diverse libraries with trillions of peptides. While translation elongation can canonically accommodate the 61 proteinogenic triplet codons, translation initiation is restricted to the native start codon AUG. Here, we investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39831308
DOI: 10.1093/nar/gkaf003
PMCID: PMC11744186

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USP7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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