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Article

Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease.

Biochimica et biophysica acta - 1 Nov 2015

Vassilakopoulou Vyronia, Calver Brian L, Thanassoulas Angelos, Beck Konrad, Hu Handan, Buntwal Luke, Smith Adrian, Theodoridou Maria, Kashir Junaid, Blayney Lynda, Livaniou Evangelia, Nounesis George, Lai F Anthony, Nomikos Michail

Abstract excerpt

Calmodulin (CaM) is a cytoplasmic calcium sensor that interacts with the cardiac ryanodine receptor (RyR2), a large Ca(2+) channel complex that mediates Ca(2+) efflux from the sarcoplasmic reticulum (SR) to activate cardiac muscle contraction. Direct CaM association with RyR2 is an important physiological regulator of cardiac muscle excitation-contraction coupling and defective CaM-RyR2 protein interaction has...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26164367
DOI: 10.1016/j.bbagen.2015.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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