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Article

The human and non-human primate developmental GTEx projects.

Nature - 1 Jan 2025

Coorens Tim H H, Guillaumet-Adkins Amy, Kovner Rothem, Linn Rebecca L, Roberts Victoria H J, Sule Amrita, Van Hoose Patrick M

Abstract excerpt

Many human diseases are the result of early developmental defects. As most paediatric diseases and disorders are rare, children are critically underrepresented in research. Functional genomics studies primarily rely on adult tissues and lack critical cell states in specific developmental windows. In parallel, little is known about the conservation of developmental programmes across non-human primate (NHP)...

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PMID: 39815096
DOI: 10.1038/s41586-024-08244-9
PMCID: PMC12013525

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