Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate.

doi:10.1038/ng.3959

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Article

Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate.

Nature genetics - 1 Dec 2017

Jasinska Anna J, Zelaya Ivette, Service Susan K, Peterson Christine B, Cantor Rita M, Choi Oi-Wa, DeYoung Joseph, Eskin Eleazar, Fairbanks Lynn A, Fears Scott, Furterer Allison E, Huang Yu S, Ramensky Vasily, Schmitt Christopher A, Svardal Hannes, Jorgensen Matthew J, Kaplan Jay R, Villar Diego, Aken Bronwen L, Flicek Paul, Nag Rishi, Wong Emily S, Blangero John, Dyer Thomas D, Bogomolov Marina, Benjamini Yoav, Weinstock George M, Dewar Ken, Sabatti Chiara, Wilson Richard K, Jentsch J David, Warren Wesley, Coppola Giovanni, Woods Roger P, Freimer Nelson B

Abstract excerpt

By analyzing multitissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalog of expression quantitative trait loci (eQTLs) in a nonhuman primate model. This catalog contains more genome-wide significant eQTLs per sample than comparable human resources and identifies sex- and age-related expression...

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PMID: 29083405
DOI: 10.1038/ng.3959
PMCID: PMC5714271

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