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Article

PHLDA2 gene polymorphisms and risk of HELLP syndrome and severe preeclampsia.

Pregnancy hypertension - 1 Jan 2020

Ding Li, Blitz Matthew J, Wing Deborah A, Epstein Aaron J, Gjessing Håkon K, Wilson Melissa L

Abstract excerpt

OBJECTIVE: Pleckstrin homology-like domain, family A, member 2 (PHLDA2) is a maternally expressed imprinted gene. Loss of imprinting in PHLDA2 is associated with abnormal placental development and fetal growth restriction. Our objective was to determine whether genetic variation in PHLDA2 is also associated with risk of HELLP syndrome and preeclampsia (PE) with severe features. STUDY DESIGN: Case (n = 162) and...

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PMID: 32062476
DOI: 10.1016/j.preghy.2020.01.013

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