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Article

Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP.

The Journal of biological chemistry - 23 Feb 2018

Kanack Adam J, Newsom Oliver J, Scaglione Kenneth Matthew

Abstract excerpt

The accumulation of misfolded proteins promotes protein aggregation and neuronal death in many neurodegenerative diseases. To counteract misfolded protein accumulation, neurons have pathways that recognize and refold or degrade aggregation-prone proteins. One U-box-containing E3 ligase, C terminus of Hsc70-interacting protein (CHIP), plays a key role in this process, targeting misfolded proteins for proteasomal...

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Identifiers

PMID: 29317501
DOI: 10.1074/jbc.RA117.000477
PMCID: PMC5827432

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Most mutations that cause spinocerebellar ataxia autosomal recessive type 16 (SCAR16) destabilize the protein quality-control E3 ligase CHIP.PMID 29317501Read ↗

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