Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in chikungunya virus nsP4 decrease viral fitness and sensitivity to the broad-spectrum antiviral 4'-Fluorouridine.

PLoS pathogens - 1 Jan 2025

Yin Peiqi, Sobolik Elizabeth B, May Nicholas A, Wang Sainan, Fayed Atef, Vyshenska Dariia, Drobish Adam M, Parks M Guston, Lello Laura Sandra, Merits Andres, Morrison Thomas E, Greninger Alexander L, Kielian Margaret

Abstract excerpt

Chikungunya virus (CHIKV) is an arthritogenic alphavirus that has re-emerged to cause large outbreaks of human infections worldwide. There are currently no approved antivirals for treatment of CHIKV infection. Recently, we reported that the ribonucleoside analog 4'-fluorouridine (4'-FlU) is a highly potent inhibitor of CHIKV replication, and targets the viral nsP4 RNA dependent RNA polymerase. In mouse models,...

Read the complete abstract on PubMed

Topics

Chikungunya virus
Animals
Antiviral Agents
Viral Nonstructural Proteins
Virus Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mice

Humans

Chikungunya Fever

Mutation

Drug Resistance, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 39804924
DOI: 10.1371/journal.ppat.1012859
PMCID: PMC11759387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in chikungunya virus nsP4 decrease viral fitness and sensitivity to the broad-spectrum antiviral 4'-Fluorouridine.PMID 39804924Read ↗

4′-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivoSemantic proximity Read ↗

Identification and Characterization of Novel Chikungunya Virus Polymerase InhibitorsSemantic proximity Read ↗

Impact of Mutations Affecting 4’-Fluorouridine Susceptibility on Fitness and Treatment Outcomes for Venezuelan Equine Encephalitis VirusSemantic proximity Read ↗

Novel Mutations in nsP2 Abolish Chikungunya Virus-Induced Transcriptional Shutoff and Make the Virus Less Cytopathic without Affecting Its Replication RatesSemantic proximity Read ↗

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.Semantic proximity Read ↗

Discovery of a novel antiviral agent targeting the nonstructural protein 4 (nsP4) of chikungunya virusSemantic proximity Read ↗

Impact of mutations affecting 4'-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus.Semantic proximity Read ↗

Chikungunya virus drug discovery: still a long way to go?Semantic proximity Read ↗

Emetine dihydrochloride inhibits Chikungunya virus nsP2 helicase and shows antiviral activity in the cell culture and mouse model of virus infectionSemantic proximity Read ↗

Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping MachinerySemantic proximity Read ↗

The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infectionSemantic proximity Read ↗

Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcriptionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.