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Article

Impact of mutations affecting 4'-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus.

Journal of virology - 17 Feb 2026

Wong Jenny, Moore Tahirah, Lewis Devin, Lieber Carolin M, Vyshenska Dariia, Sobolik Elizabeth B, Zimmermann Sarah, Painter George R, Plemper Richard K, Greninger Alexander L, Cox Robert M

Abstract excerpt

Venezuelan equine encephalitis virus (VEEV) is a prototypical encephalitic alphavirus. Members of the Alphavirus genus are found across the globe, transmitted by arthropod vectors, and cause significant disease burdens in humans and animals. There are currently no FDA-approved antivirals for human use against any member of the Alphavirus genus. While a vaccine exists against chikungunya virus (CHIKV), a member of...

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Antiviral Agents
Cell Line
Chlorocebus aethiops
Drug Resistance, Viral
Treatment Outcome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virus Replication

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Identifiers

PMID: 41537597
DOI: 10.1128/jvi.01541-25
PMCID: PMC12911897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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