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Article

Genetically Confirmed Optimal Causal Association of Cerebrospinal Fluid Metabolites With Hemorrhagic Stroke.

Journal of neurochemistry - 1 Jan 2025

Shen Yingjie, Wang Yaolou, Shen Yongze, Zhang Xi, Yu Zhao, Xu Hangjia, Lin Tie, Rong Yiwei, Guo Chunmei, Gao Aili, Liang Hongsheng

Abstract excerpt

Hemorrhagic stroke (HS) mainly includes intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), both of which seriously affect the patient's prognosis. Cerebrospinal fluid (CSF) metabolites and HS showed a link in observational studies. However, the causal association between them is not clear. We aimed to establish the optimal causality of CSF metabolites with HS. Mendelian randomization (MR) was...

Read the complete abstract on PubMed

Topics

Humans
Hemorrhagic Stroke
Mendelian Randomization Analysis
Male
Subarachnoid Hemorrhage
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Biomarkers

Cerebral Hemorrhage

Source

Identifiers

PMID: 39788786
DOI: 10.1111/jnc.16293

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