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Article

Irx1 mechanisms for oral epithelial basal stem cell plasticity during reepithelialization after injury

8 Jan 2025

Abstract excerpt

The oral mucosa undergoes daily insults, and stem cells in the epithelial basal cell layer regenerate gingiva tissue to maintain oral health. The Iroquois Homeobox 1 (IRX1) protein is expressed in the stem cell niches in human/mouse oral epithelium and mesenchyme under homeostasis. We found that Irx1+/- heterozygous (Het) mice have delayed wound closure, delayed morphological changes of regenerated epithelium,...

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PMID: 39782692
DOI: 10.1172/jci.insight.179815

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