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Article

Basal stem cells contribute to squamous cell carcinomas in the oral cavity

28 Jan 2013

Abstract excerpt

The cells of origin of oral cavity squamous cell carcinoma (OCSCC) are unknown. We used a cell lineage tracing approach (adult K14-CreER(TAM); ROSA26 mice transiently treated with tamoxifen) to identify and track normal epithelial stem cells (SCs) in mouse tongues by X-gal staining and to determine if these cells become neoplastically transformed by treatment with a carcinogen, 4-nitroquinoline 1-oxide (4-NQO)....

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PMID: 23358851
DOI: 10.1093/carcin/bgt021

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