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Article

Organoids from human tooth showing epithelial stemness phenotype and differentiation potential.

Cellular and molecular life sciences : CMLS - 26 Feb 2022

Hemeryck Lara, Hermans Florian, Chappell Joel, Kobayashi Hiroto, Lambrechts Diether, Lambrichts Ivo, Bronckaers Annelies, Vankelecom Hugo

Abstract excerpt

Insight into human tooth epithelial stem cells and their biology is sparse. Tissue-derived organoid models typically replicate the tissue's epithelial stem cell compartment. Here, we developed a first-in-time epithelial organoid model starting from human tooth. Dental follicle (DF) tissue, isolated from unerupted wisdom teeth, efficiently generated epithelial organoids that were long-term expandable. The...

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Identifiers

PMID: 35217915
DOI: 10.1007/s00018-022-04183-8
PMCID: PMC8881251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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