Article

Overcoming Bottlenecks in AAV Manufacturing for Gene Therapy

2018-11-06

Abstract excerpt

Recombinant adeno-associated viral vectors (rAAV) have emerged as one of the most powerful tools for gene delivery to treat human disease. Significant advancements in vector development and manufacturing methods, along with promising results in the clinic, has initiated an extraordinary interest in drug development for gene therapies and commercialization. It is an exciting time for AAV-mediated gene therapy; in 2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aaf39dd4-0428-50b3-b79e-4013779b7931
DOI: 10.18609/cgti.2018.083

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Overcoming Bottlenecks in AAV Manufacturing for Gene TherapyDOI 10.18609/cgti.2018.083Read

Progress and challenges in viral vector manufacturingSemantic proximity Read

Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturingSemantic proximity Read

Viral vector manufacturing: how to address current and future demands?Semantic proximity Read

Manufacturing of recombinant adeno-associated viral vectors: new technologies are welcomeSemantic proximity Read

Manufacturing of recombinant adeno-associated viral vectors for clinical trialsSemantic proximity Read

AAV-Based Gene Therapy: Opportunities, Risks, and Scale-Up StrategiesSemantic proximity Read

Unravelling the essential elements for recombinant adeno-associated virus (rAAV) production in animal cell-based platformsSemantic proximity Read

AAV vector manufacturing process design and scalability - Bending the trajectory to address vector-associated immunotoxicitiesSemantic proximity Read

Gene therapy: challenges in cell culture scale-upSemantic proximity Read

Advancing AAV production with high-throughput screening and transcriptomicsSemantic proximity Read

Design Strategies of Adeno-Associated Virus (AAV) Vectors in Gene TherapySemantic proximity Read

Considerations for Preclinical Safety Assessment of Adeno-Associated Virus Gene Therapy ProductsSemantic proximity Read