Article
The structure of a Michaelis serpin-protease complex.
Nature structural biology - 1 Nov 2001
Ye S, Cech A L, Belmares R, Bergstrom R C, Tong Y, Corey D R, Kanost M R, Goldsmith E J
Abstract excerpt
Serine protease inhibitors (serpins) regulate the activities of circulating proteases. Serpins inhibit proteases by acylating the serine hydroxyl at their active sites. Before deacylation and complete proteolysis of the serpin can occur, massive conformational changes are triggered in the serpin while maintaining the covalent linkage between the protease and serpin. Here we report the structure of a...
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