Article
Evidence for multiple modes of neutrophil serine protease recognition by the EAP family of Staphylococcal innate immune evasion proteins.
Protein science : a publication of the Protein Society - 1 Feb 2018
Stapels Daphne A C, Woehl Jordan L, Milder Fin J, Tromp Angelino T, van Batenburg Aernoud A, de Graaf Wilco C, Broll Samuel C, White Natalie M, Rooijakkers Suzan H M, Geisbrecht Brian V
Abstract excerpt
Neutrophils contain high levels of chymotrypsin-like serine proteases (NSPs) within their azurophilic granules that have a multitude of functions within the immune system. In response, the pathogen Staphylococcus aureus has evolved three potent inhibitors (Eap, EapH1, and EapH2) that protect the bacterium as well as several of its secreted virulence factors from the degradative action of NSPs. We previously...
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