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Article

Interaction of α-synuclein with DJ-1 in homodimer and L166P mutant monomer forms in Parkinson's disease: a molecular dynamics study.

Journal of biomolecular structure & dynamics - 1 Feb 2026

Alipour Mozhgan, Hajipour-Verdom Behnam, Zali Alireza, Ashrafi Farzad, Abdolmaleki Parviz, Oraee-Yazdani Saeed, Akhlaghdoust Meisam, Karimi Nastaran

Abstract excerpt

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by the formation of Lewy bodies, which are primarily composed of misfolded α-Synuclein (α-Syn). DJ-1 is a crucial protein involved in the correct folding of α-Syn, and mutations impairing its function are associated with the onset of PD. One such mutation, the L166P substitution in DJ-1, which has been linked to early-onset...

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PMID: 39773404
DOI: 10.1080/07391102.2024.2446660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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