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Article

In silico analysis of prion protein mutants: a comparative study by molecular dynamics approach.

Cell biochemistry and biophysics - 1 Jan 2013

Doss C George Priya, Rajith B, Rajasekaran R, Srajan Jain, Nagasundaram N, Debajyoti C

Abstract excerpt

Polymorphisms in the human prion proteins lead to amino acid substitutions by the conversion of PrPC to PrPSc and amyloid formation, resulting in prion diseases such as familial Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinker disease and fatal familial insomnia. Cation-π interaction is a non-covalent binding force that plays a significant role in protein stability. Here, we employ a novel approach by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23723004
DOI: 10.1007/s12013-013-9663-z

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