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Article

Mechanism of BAG1 repair on Parkinson's disease-linked DJ1 mutation.

Journal of biomolecular structure & dynamics - 1 Jan 2012

Chen Calvin Yu-Chian

Abstract excerpt

Mutant oncogene DJ1 L166P has been linked to a familial form of early-onset Parkinson's disease (PD). The DJ1 mutant deformed C-terminal helices and prevented the formation of a functional DJ1 dimer. Intriguingly, chaperon modulator, BCL2-associated athanogene (BAG1), has been shown to repair DJ1 mutant and restore its functions. Molecular simulation techniques were employed to elucidate protein-protein...

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Source

Identifiers

PMID: 22571429
DOI: 10.1080/07391102.2012.674182

Genes

BAG1
BCL2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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