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Article

On the oligomeric state of DJ-1 protein and its mutants associated with Parkinson Disease. A combined computational and in vitro study.

The Journal of biological chemistry - 24 Aug 2007

Herrera Fernando E, Zucchelli Silvia, Jezierska Aneta, Lavina Zeno Scotto, Gustincich Stefano, Carloni Paolo

Abstract excerpt

Mutations in the DJ-1 protein are present in patients suffering from familial Parkinson disease. Here we use computational methods and biological assays to investigate the relationship between DJ-1 missense mutations and the protein oligomeric state. Molecular dynamics calculations suggest that: (i) the structure of DJ-1 wild type (WT) in aqueous solution, in both oxidized and reduced forms, is similar to the...

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Identifiers

PMID: 17504761
DOI: 10.1074/jbc.M701013200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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