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A reporter cell line for the automated quantification of SARS-CoV-2 infection in living cells

29 Sept 2022

Abstract excerpt

The SARS-CoV-2 pandemic and the urgent need for massive antiviral testing highlighted the lack of a good cell-based assay that allowed for a fast, automated screening of antivirals in high-throughput content with minimal handling requirements in a BSL-3 environment. The present paper describes the construction of a green fluorescent substrate that, upon cleavage by the SARS-CoV-2 main protease, re-localizes from...

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PMID: 36246297
DOI: 10.3389/fmicb.2022.1031204

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