Article
The Influence of Genetic Polymorphisms in Cytochrome P450 (CYP1A1 and 2D6) Gene on the Susceptibility to Philadelphia Negative Chronic Myeloid Leukemia in Sudanese Patients.
International journal of molecular sciences - 17 Dec 2024
Elderdery Abozer Y, Idris Hadeil M E, Alruwaili Saud Nahar L, Tebien Entesar M, Alsrhani Abdullah, Alenazy Fawaz O, Alzahrani Badr, Manni Emad, Elkhalifa Ahmed M E, Mills Jeremy
Abstract excerpt
The most frequent type of leukemia in Africa is chronic myeloid leukemia (CML). The genetic background of the rarer Philadelphia chromosome (Ph) Ph-ve (BCR-ABL-ve) subform of CML is largely unknown in African patients. Therefore, in this study, we aimed to investigate the role of CYP1A1 and 2D6 SNPs in the pathogenesis of Ph-ve CML in the Sudanese population. A total of 126 patients were selected for analysis....
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