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Article

Causal Relationship Between Physical Activity and Thymic Tumors Mediated by Circulating Cytokines: A Mendelian Randomization Mediation Analysis.

International journal of molecular sciences - 16 Dec 2024

Sun Yulin, Hao Shuaipeng

Abstract excerpt

Physical activity reduces chronic disease risk and enhances immune function, but its causal relationship with thymic tumors-rare neoplasms of the anterior mediastinum-remains unclear. This study investigated whether physical activity reduces thymic tumor risk and whether circulating cytokines mediate this effect. We performed a two-sample Mendelian randomization (MR) analysis using genetic variants as...

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PMID: 39769247
DOI: 10.3390/ijms252413485

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