Article
Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis.
BMC medicine - 11 Jan 2022
Bouras Emmanouil, Karhunen Ville, Gill Dipender, Huang Jian, Haycock Philip C, Gunter Marc J, Johansson Mattias, Brennan Paul, Key Tim, Lewis Sarah J, Martin Richard M, Murphy Neil, Platz Elizabeth A, Travis Ruth, Yarmolinsky James, Zuber Verena, Martin Paul, Katsoulis Michail, Freisling Heinz, Nøst Therese Haugdahl, Schulze Matthias B, Dossus Laure, Hung Rayjean J, Amos Christopher I, Ahola-Olli Ari, Palaniswamy Saranya, Männikkö Minna, Auvinen Juha, Herzig Karl-Heinz, Keinänen-Kiukaanniemi Sirkka, Lehtimäki Terho, Salomaa Veikko, Raitakari Olli, Salmi Marko, Jalkanen Sirpa, Jarvelin Marjo-Riitta, Dehghan Abbas, Tsilidis Konstantinos K
Abstract excerpt
BACKGROUND: Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) analysis. METHODS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.