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Article

Evolutionary Adaptations in Biliverdin Reductase B: Insights into Coenzyme Dynamics and Catalytic Efficiency.

International journal of molecular sciences - 10 Dec 2024

Lee Eunjeong, Redzic Jasmina S, Eisenmesser Elan Zohar

Abstract excerpt

Biliverdin reductase B (BLVRB) is a redox regulator that catalyzes nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductions of multiple substrates, including flavins and biliverdin-β. BLVRB has emerging roles in redox regulation and post-translational modifications, highlighting its importance in various physiological contexts. In this study, we explore the structural and functional differences...

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Allosteric Regulation
Allosteric Site
Catalysis
Catalytic Domain
Coenzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidation-Reduction

Oxidoreductases Acting on CH-CH Group Donors

Protein Conformation

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PMID: 39768998
DOI: 10.3390/ijms252413233

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