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Spectroscopic studies on human androglobin regulated by its heme distal Gln12 and IQ motif via interaction with calmodulin.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy - 15 Dec 2026

Ren Zhi-Hao, Sun Li-Juan, Gao Shu-Qin, Lin Ying-Wu

Abstract excerpt

Androglobin (Adgb) was discovered as the fifth mammalian globin, yet its structural and functional properties remain incompletely understood. In this study, we overexpressed the heme-binding globin domain of Adgb with stabilizing mutations (C114S/C190S, denoted Adgb-SS) and investigated the role of its heme distal residue Gln12 through the generation of Q12H and Q12Y mutants. The protein structures were predicted...

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PMID: 42372363
DOI: 10.1016/j.saa.2026.128328

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