Spectroscopic studies on human androglobin regulated by its heme distal Gln12 and IQ motif via interaction with calmodulin.

Abstract excerpt

Androglobin (Adgb) was discovered as the fifth mammalian globin, yet its structural and functional properties remain incompletely understood. In this study, we overexpressed the heme-binding globin domain of Adgb with stabilizing mutations (C114S/C190S, denoted Adgb-SS) and investigated the role of its heme distal residue Gln12 through the generation of Q12H and Q12Y mutants. The protein structures were predicted...

Topics

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• Amino Acid Motifs
• Calmodulin
• Globins
• Heme
• Molecular Dynamics Simulation