Article
BluB cannibalizes flavin to form the lower ligand of vitamin B12.
Nature - 22 Mar 2007
Taga Michiko E, Larsen Nicholas A, Howard-Jones Annaleise R, Walsh Christopher T, Walker Graham C
Abstract excerpt
Vitamin B12 (cobalamin) is among the largest known non-polymeric natural products, and the only vitamin synthesized exclusively by microorganisms. The biosynthesis of the lower ligand of vitamin B(12), 5,6-dimethylbenzimidazole (DMB), is poorly understood. Recently, we discovered that a Sinorhizobium meliloti gene, bluB, is necessary for DMB biosynthesis. Here we show that BluB triggers the unprecedented...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.