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Article

Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis.

Journal of translational medicine - 6 Jan 2025

Fang Chuchun, Liu Xuewei, Yu Chen, Li Songlin, Liu Xueying, Qiu Shifeng, Liang Hongbin, Ou Caiwen, Xiu Jiancheng

Abstract excerpt

BACKGROUND: Cancer-targeted therapies are progressively pivotal in oncological care. Observational studies underscore the emergence of cancer therapy-related cardiovascular toxicity (CTR-CVT), impacting patient outcomes. We aimed to investigate the causal relationship between different types of cancer-targeted therapies and cardiovascular disease (CVD) outcomes through a two-sample Mendelian randomization (MR)...

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Identifiers

PMID: 39762845
DOI: 10.1186/s12967-024-06027-4
PMCID: PMC11702226

Genes

VEGFA
FGFR1
FLT1
MAP2K2

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