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Article

Loss of TDP ‐43 Splicing Repression Occurs in Myonuclei of Inclusion Body Myositis Patients

6 Jan 2025

Abstract excerpt

OBJECTIVE: Inclusion body myositis (IBM) is an idiopathic inflammatory myopathy with muscle pathology characterized by endomysial inflammation, rimmed vacuoles, and cytoplasmic mislocalization of transactive response DNA-binding protein 43 (TDP-43). We aimed to determine whether loss of TDP-43 splicing repression led to the production of "cryptic peptides" that could be detected in muscle biopsies as a useful...

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PMID: 39757935
DOI: 10.1002/ana.27167

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