Article
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer.
Nature communications - 16 Apr 2021
Lindskrog Sia Viborg, Prip Frederik, Lamy Philippe, Taber Ann, Groeneveld Clarice S, Birkenkamp-Demtröder Karin, Jensen Jørgen Bjerggaard, Strandgaard Trine, Nordentoft Iver, Christensen Emil, Sokac Mateo, Birkbak Nicolai J, Maretty Lasse, Hermann Gregers G, Petersen Astrid C, Weyerer Veronika, Grimm Marc-Oliver, Horstmann Marcus, Sjödahl Gottfrid, Höglund Mattias, Steiniche Torben, Mogensen Karin, de Reyniès Aurélien, Nawroth Roman, Jordan Brian, Lin Xiaoqi, Dragicevic Dejan, Ward Douglas G, Goel Anshita, Hurst Carolyn D, Raman Jay D, Warrick Joshua I, Segersten Ulrika, Sikic Danijel, van Kessel Kim E M, Maurer Tobias, Meeks Joshua J, DeGraff David J, Bryan Richard T, Knowles Margaret A, Simic Tatjana, Hartmann Arndt, Zwarthoff Ellen C, Malmström Per-Uno, Malats Núria, Real Francisco X, Dyrskjøt Lars
Abstract excerpt
The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients diagnosed with NMIBC (n = 834). Transcriptomic analysis identifies four classes (1, 2a, 2b and 3) reflecting tumor biology and disease aggressiveness. Both transcriptome-based subtyping and the...
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