Article
CHP2 Modifies Chronic Pseudomonas aeruginosa Airway Infection Risk in Cystic Fibrosis.
Annals of the American Thoracic Society - 1 May 2025
Faino Anna V, Gordon William W, Buckingham Kati, Stilp Adrienne M, Pace Rhonda G, Raraigh Karen S, Collaco Joseph M, Zhou Yi-Hui, Dang Hong, O'Neal Wanda, Knowles Michael K, Cutting Garry R, Rosenfeld Margaret, Bamshad Michael J, Gibson Ronald L, Blue Elizabeth E
Abstract excerpt
Rationale: Chronic Pseudomonas aeruginosa (Pa) airway infection is common and a key contributor to diminished lung function and early mortality in persons with cystic fibrosis (PwCF). Risk factors for chronic Pa among PwCF include CFTR (cystic fibrosis transmembrane conductance regulator) genotype, genetic modifiers, and environmental factors. Intensive antibiotic therapy and highly effective modulators do not...
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