Article
DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis.
The clinical respiratory journal - 1 Nov 2016
Viel Marion, Hubert Dominique, Burgel Pierre-Regis, Génin Emmanuelle, Honoré Isabelle, Martinez Brigitte, Gaitch Natacha, Chapron Jeanne, Kanaan Reem, Dusser Daniel, Girodon Emmanuelle, Bienvenu Thierry
Abstract excerpt
BACKGROUND AND AIMS: Pseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) patients is associated with worse long-term pulmonary disease and shorter survival, and chronic Pa infection (CPA) is associated with reduced lung function, faster rate of lung decline, increased rates of exacerbations and shorter survival. By using exome sequencing and extreme phenotype design, it was recently shown that isoforms...
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