Article
The Candida albicans reference strain SC5314 contains a rare, dominant allele of the transcription factor Rob1 that modulates filamentation, biofilm formation, and oral commensalism.
mBio - 31 Oct 2023
Glazier Virginia E, Kramara Juraj, Ollinger Tomye, Solis Norma V, Zarnowski Robert, Wakade Rohan S, Kim Min-Ju, Weigel Gabriel J, Liang Shen-Huan, Bennett Richard J, Wellington Melanie, Andes David R, Stamnes Mark A, Filler Scott G, Krysan Damian J
Abstract excerpt
IMPORTANCE: Candida albicans is a commensal fungus that colonizes the human oral cavity and gastrointestinal tract but also causes mucosal as well as invasive disease. The expression of virulence traits in C. albicans clinical isolates is heterogeneous and the genetic basis of this heterogeneity is of high interest. The C. albicans reference strain SC5314 is highly invasive and expresses robust filamentation and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.