Article

Immunoprofiling of human uterine mast cells identifies three phenotypes and expression of ERβ and glucocorticoid receptor

2017-06-22

Abstract excerpt

<h4>Background: </h4> Human mast cells (MCs) are long-lived tissue-resident immune cells characterised by granules containing the proteases chymase and/or tryptase. Their phenotype is modulated by their tissue microenvironment. The human uterus has an outer muscular layer (the myometrium) surrounding the endometrium, both of which play an important role in supporting a pregnancy. The endometrium is a sex steroid t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2637f0bd-c420-5eb0-ae87-541772d75369
DOI: 10.12688/f1000research.11432.2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunoprofiling of human uterine mast cells identifies three phenotypes and expression of ERβ and glucocorticoid receptorDOI 10.12688/f1000research.11432.2Read

Immunoprofiling of human uterine mast cells identifies three phenotypes and expression of ERβ and glucocorticoid receptorSemantic proximity Read

The transcriptional program, functional heterogeneity, and clinical targeting of mast cellsSemantic proximity Read

Is it time for a new classification of mast cells? What do we know about mast cell heterogeneity?Semantic proximity Read

Human intraepithelial mast cell differentiation and effector function are directed by TGF-β signalingSemantic proximity Read

Single-Cell RNA Sequencing Reveals the Immune Landscape of Granulomatous MastitisSemantic proximity Read

Identification and Clinical Validation of Key Immune Cells in Endometrial Cancer: A Focus on Mast Cells and Dendritic CellsSemantic proximity Read

Single cell transcriptomics reveal mast cell heterogeneity in the human gutSemantic proximity Read

Spatial Phenotype of the Mast Cell Population in Endometritis of Various Severities.Semantic proximity Read

Mast cells: Versatile regulators of inflammation, tissue remodeling, host defense and homeostasisSemantic proximity Read

Human mast cells arise from a common circulating progenitor.Semantic proximity Read

Mast cells, their subtypes, and relation to asthma phenotypes.Semantic proximity Read

Regulation of mast cell responses in health and disease.Semantic proximity Read