Article
Study on Relationships of Tumor Status and Gene Polymorphism With Blood Concentration of MTX and Toxicities in 63 Pediatric Mature B Cell Lymphoma in Chinese Population.
Technology in cancer research & treatment - 1 Jan 2000
Huang Shuang, Jin Lin, Yang Jing, Duan Long Yan, Zhang Meng, Zhou Ju Chun, Zhang Hong Yong
Abstract excerpt
OBJECTIVE: This study investigated the relationships of tumor status (stage, renal involvement, bone marrow status, bulky disease, liver function), tumor gene polymorphism, and methotrexate (MTX) dosage (stratified by treatment group) with blood MTX levels and adverse reactions (ADR). METHODS: We retrospectively reviewed 63 mature B cell lymphoma patients who were treated in our center. Genotyping of the MTHFR...
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