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Influence of methylenetetrahydrofolate reductase gene polymorphisms on the outcome of pediatric patients with non-Hodgkin lymphoma treated with high-dose methotrexate.

Leukemia & lymphoma - 1 Dec 2013

D'Angelo Velia, Ramaglia Maria, Iannotta Adriana, Francese Matteo, Pota Elvira, Affinita Maria Carmen, Pecoraro Giulia, Indolfi Cristiana, Di Martino Martina, Di Pinto Daniela, Buffardi Salvatore, Poggi Vincenzo, Indolfi Paolo, Casale Fiorina

Abstract excerpt

High-dose methotrexate (MTX) is a key component of most treatment protocols for childhood and adolescent non-Hodgkin lymphoma (NHL). Recent studies have suggested that the toxicity of antifolate drugs, such as MTX, is affected by inherited single nucleotide polymorphisms (SNPs) in folate metabolizing genes. The aim of our study was to investigate the potential influence of the C677T and A1298C genetic variants of...

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Identifiers

PMID: 23488607
DOI: 10.3109/10428194.2013.784758

Genes

MTHFR

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