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Article

GPI transamidase complex is required for primordial germ cell migration and development in zebrafish.

Journal of molecular cell biology - 12 Jun 2025

Zhang Weiying, Li Yaqi, Chen Jing, Yao Likun, Zhang Bingjie, Zhang Lin, Liu Boqi, Shen Weimin, Meng Anming, Wu Xiaotong

Abstract excerpt

Proteins without transmembrane domains could be anchored to the cell surface for regulating various biological processes when covalently linked to glycosylphosphatidylinositol (GPI) molecules by the GPI transamidase (GPIT) complex. However, it remains poorly understood whether and how the GPIT complex affects primordial germ cell (PGC) development. In this study, we report the important roles of the GPIT complex...

Read the complete abstract on PubMed

Topics

Animals
Zebrafish
Cell Movement
Germ Cells
Zebrafish Proteins
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Embryo, Nonmammalian

Gene Expression Regulation, Developmental

Pseudopodia

Embryonic Development

Acyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 39741393
DOI: 10.1093/jmcb/mjae058
PMCID: PMC12159598

Genes

PGC
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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