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Whole genome sequencing reveals candidate causal genetic variants for spastic syndrome in Holstein cattle.

Scientific reports - 28 Dec 2024

Jacinto Joana G P, Letko Anna, Häfliger Irene M, Akyürek Eylem Emek, Sacchetto Roberta, Gentile Arcangelo, Drögemüller Cord

Abstract excerpt

Bovine spastic syndrome (SS) is a progressive, adult-onset neuromuscular disorder (NMD). SS is inherited but the mode of inheritance is unclear. The aim of this study was to characterize the phenotype and to identify a possible genetic cause of SS by whole-genome sequencing (WGS) and focusing on protein-changing variants. Seven affected unrelated Holstein cattle of both sexes were referred for SS at a mean age of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39732776
DOI: 10.1038/s41598-024-82446-z
PMCID: PMC11682090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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