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Article

Congenital bovine spinal dysmyelination is caused by a missense mutation in the SPAST gene.

Neurogenetics - 1 May 2010

Thomsen Bo, Nissen Peter H, Agerholm Jørgen S, Bendixen Christian

Abstract excerpt

Bovine spinal dysmyelination (BSD) is a recessive congenital neurodegenerative disease in cattle (Bos taurus) characterized by pathological changes of the myelin sheaths in the spinal cord. The occurrence of BSD is a longstanding problem in the American Brown Swiss (ABS) breed and in several European cattle breeds upgraded with ABS. Here, we show that the disease locus on bovine chromosome 11 harbors the SPAST...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation, Missense

Share to Myelin Sheath

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Share to Spastic Paraplegia, Hereditary

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Source

Open in PubMed Open full text

Identifiers

PMID: 19714378
DOI: 10.1007/s10048-009-0214-0
PMCID: PMC2854348

Genes

SPAST

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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