Article
Genomic evidence supporting the clonal expansion of extensively drug-resistant tuberculosis bacteria belonging to a rare proto-Beijing genotype.
Emerging microbes & infections - 1 Dec 2020
Srilohasin Prapaporn, Prammananan Therdsak, Faksri Kiatichai, Phelan Jody E, Suriyaphol Prapat, Kamolwat Phalin, Smithtikarn Saijai, Disratthakit Areeya, Regmi Sanjib Mani, Leechawengwongs Manoon, Twee-Hee Ong Rick, Teo Yik Ying, Tongsima Sissades, Clark Taane G, Chaiprasert Angkana
Abstract excerpt
Tuberculosis disease (TB), caused by Mycobacterium tuberculosis, is a major public health issue in Thailand. The high prevalence of modern Beijing (Lineage 2.2.1) strains has been associated with multi- and extensively drug-resistant infections (MDR-, XDR-TB), complicating disease control. The impact of rarer proto-Beijing (L2.1) strains is less clear. In our study of thirty-seven L2.1 clinical isolates spanning...
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