Unraveling the impact of SARS-CoV-2 mutations on immunity: insights from innate immune recognition to antibody and T cell responses.

doi:10.3389/fimmu.2024.1412873

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Unraveling the impact of SARS-CoV-2 mutations on immunity: insights from innate immune recognition to antibody and T cell responses.

Frontiers in immunology - 1 Jan 2024

Bayarri-Olmos Rafael, Sutta Adrian, Rosbjerg Anne, Mortensen Mie Mandal, Helgstrand Charlotte, Nielsen Per Franklin, Pérez-Alós Laura, González-García Beatriz, Johnsen Laust Bruun, Matthiesen Finn, Egebjerg Thomas, Hansen Cecilie Bo, Sette Alessandro, Grifoni Alba, da Silva Antunes Ricardo, Garred Peter

Abstract excerpt

Throughout the COVID-19 pandemic, the emergence of new viral variants has challenged public health efforts, often evading antibody responses generated by infections and vaccinations. This immune escape has led to waves of breakthrough infections, raising questions about the efficacy and durability of immune protection. Here we focus on the impact of SARS-CoV-2 Delta and Omicron spike mutations on ACE-2 receptor...

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PMID: 39720734
DOI: 10.3389/fimmu.2024.1412873
PMCID: PMC11666439

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