Article
Genomics, Signaling, and Treatment of Waldenström Macroglobulinemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Mar 2017
Hunter Zachary R, Yang Guang, Xu Lian, Liu Xia, Castillo Jorge J, Treon Steven P
Abstract excerpt
Next-generation sequencing has revealed recurring somatic mutations in Waldenström macroglobulinemia (WM). Commonly recurring mutations include MYD88 (95% to 97%), CXCR4 (30% to 40%), ARID1A (17%), and CD79B (8% to 15%). Diagnostic discrimination of WM from overlapping B-cell malignancies is aided by MYD88 mutation status. Transcription is affected by MYD88 and CXCR4 mutations and includes overexpression of genes...
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