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Pyruvate Abundance Confounds Aminoglycoside Killing of Multidrug-Resistant Bacteria via Glutathione Metabolism

1 Jan 2024

Abstract excerpt

To explore whether the metabolic state reprogramming approach may be used to explore previously unknown metabolic pathways that contribute to antibiotic resistance, especially those that have been neglected in previous studies, pyruvate reprogramming was performed to reverse the resistance of multidrug-resistant Edwardsiella tarda . Surprisingly, we identified a pyruvate-regulated glutathione system that occurs...

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PMID: 39697188
DOI: 10.34133/research.0554

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